Dultz Group

Nuclear pore complexes transport a variety of different macromolecules across the nuclear envelope. In addition, they interact with cytoplasmic and nuclear structures like the cytoskeleton and chromatin. But can each nuclear pore complex perform all of these functions? The Dultz group investigates how nuclear pore complexes of different composition arise and in what respect they differ in their functionality. We use budding yeast as our model system and use genetics and quantitative microsopy methods. We are particularly interested in the interaction of nuclear pore complexes with chromatin, nascent mRNA and the mRNA export machinery. How does the nuclear pore complex contribute to the regulation of transcription, posttranscriptional processing and mRNA export?