Institute of Biochemistry

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Selection of recent papers

external pageModel for the architecture of caveolae based on a flexible, net-like assembly of Cavin1 and Caveolin discs.
Stoeber M, Schellenberger P, Siebert CA, Leyrat C, Helenius A, Grünewald K.
Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8069-E8078.
PMID: 27834731

external pageCargo Capture and Bulk Flow in the Early Secretory Pathway.
Barlowe C, Helenius A.
Annu Rev Cell Dev Biol. 2016 Oct 6;32:197-222.
PMID: 27298089

external pageIn Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation.
Stauffer S, Nebioglu F, Helenius A.
J Vis Exp. 2016 Mar 27;(109). doi: 10.3791/53909.

external pagePI3Kγ Is Critical for Dendritic Cell-Mediated CD8+ T Cell Priming and Viral Clearance during Influenza Virus Infection.
Nobs SP, Schneider C, Heer AK, Huotari J, Helenius A, Kopf M.
PLoS Pathog. 2016 Mar 31;12(3):e1005508. doi: 10.1371/journal.ppat.1005508. eCollection 2016 Mar.

external pageA SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes.
Gschweitl M, Ulbricht A, Barnes CA, Enchev RI, Stoffel-Studer I, Meyer-Schaller N, Huotari J, Yamauchi Y, Greber UF, Helenius A, Peter M.
Elife. 2016 Mar 23;5. pii: e13841. doi: 10.7554/eLife.13841.

external pageHCMV Induces Macropinocytosis for Host Cell Entry in Fibroblasts.
Hetzenecker S, Helenius A, Krzyzaniak MA.
Traffic. 2016 Apr;17(4):351-68. doi: 10.1111/tra.12355. Epub 2016 Feb 11.

external pageVaccinia Virus Infection Requires Maturation of Macropinosomes.
Rizopoulos Z, Balistreri G, Kilcher S, Martin CK, Syedbasha M, Helenius A, Mercer J.
Traffic. 2015 Aug; 16(8):814-31. doi: 10.1111/tra.12290. Epub 2015 May 6.

external pageInfluenza A virus uses the aggresome processing machinery for host cell entry.
Banerjee I, Miyake Y, Nobs SP, Schneider C, Horvath P, Kopf M, Matthias P, Helenius A, Yamauchi Y.
Science. 2014 Oct 24; 346(6208):473-7. doi: 10.1126/science.1257037.

external pageThe host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication.
Balistreri G, Horvath P, Schweingruber C, Zünd D, McInerney G, Merits A, Mühlemann O, Azzalin C, Helenius A.
Cell Host Microbe. 2014 Sep 10; 16(3):403-11. doi: 10.1016/j.chom.2014.08.007.

external pageStepwise priming by acidic pH and a high K+ concentration is required for efficient uncoating of influenza A virus cores after penetration.
Stauffer S, Feng Y, Nebioglu F, Heilig R, Picotti P, Helenius A.
J Virol. 2014 Nov; 88(22):13029-46. doi: 10.1128/JVI.01430-14. Epub 2014 Aug 27.

external pageLarge scale RNAi reveals the requirement of nuclear envelope breakdown for nuclear import of human papillomaviruses.
Aydin I, Weber S, Snijder B, Samperio Ventayol P, Kühbacher A, Becker M, Day PM, Schiller JT, Kann M, Pelkmans L, Helenius A, Schelhaas M.
PLoS Pathog. 2014 May 29; 10(5):e1004162. doi: 10.1371/journal.ppat.1004162. eCollection 2014 May.

external pageGenome-wide small interfering RNA screens reveal VAMP3 as a novel host factor required for Uukuniemi virus late penetration.
Meier R, Franceschini A, Horvath P, Tetard M, Mancini R, von Mering C, Helenius A, Lozach PY.
J Virol. 2014 Aug; 88(15):8565-78. doi: 10.1128/JVI.00388-14. Epub 2014 May 21.

external pageSpecific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens.
Franceschini A, Meier R, Casanova A, Kreibich S, Daga N, Andritschke D, Dilling S, Rämö P, Emmenlauer M, Kaufmann A, Conde-Álvarez R, Low SH, Pelkmans L, Helenius A, Hardt WD, Dehio C, von Mering C.
Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):4548-53. doi: 10.1073/pnas.1402353111. Epub 2014 Mar 10.

external pagesiRNA screen of early poxvirus genes identifies the AAA+ ATPase D5 as the virus genome-uncoating factor.
Kilcher S, Schmidt FI, Schneider C, Kopf M, Helenius A, Mercer J.
Cell Host Microbe. 2014 Jan 15; 15(1):103-12. doi: 10.1016/j.chom.2013.12.008.

external pageRole of DC-SIGN in Lassa virus entry into human dendritic cells.
Goncalves AR, Moraz ML, Pasquato A, Helenius A, Lozach PY, Kunz S.
J Virol. 2013 Nov;87(21):11504-15. doi: 10.1128/JVI.01893-13. Epub 2013 Aug 21.

external pageArchitecture of respiratory syncytial virus revealed by electron cryotomography.
Liljeroos L, Krzyzaniak MA, Helenius A, Butcher SJ.
Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11133-8. doi: 10.1073/pnas.1309070110. Epub 2013 Jun 17.

external pageVirus entry: what has pH got to do with it?
Helenius A.
Nat Cell Biol. 2013 Feb;15(2):125. doi: 10.1038/ncb2678.

external pageInvestigating Endocytic Pathways to the Endoplasmic Reticulum and to the Cytosol Using SNAP-Trap.
Geiger R, Luisoni S, Johnsson K, Greber UF, Helenius A.
Traffic. 2013 Jan;14(1):36-46.

external pageRNAi screening reveals proteasome- and Cullin3-dependent stages in vaccinia virus infection.
Mercer J, Snijder B, Sacher R, Burkard C, Bleck CK, Stahlberg H, Pelkmans L, Helenius A.
Cell Rep. 2012 Oct 25;2(4):1036-474.

external pageEntry of human papillomavirus type 16 by actin-dependent, clathrin- and lipid raft-independent endocytosis.
Schelhaas M, Shah B, Holzer M, Blattmann P, Kühling L, Day PM, Schiller JT, Helenius A.
PLoS Pathog. 2012;8(4).

external pageDirect identification of ligand-receptor interactions on living cells and tissues.
Frei AP, Jeon OY, Kilcher S, Moest H, Henning LM, Jost C, Plückthun A, Mercer J, Aebersold R, Carreira EM, Wollscheid B.
Nat Biotechnol. 2012 Oct;30 (10):997-1001.

external pageCooperative vaccinia infection demonstrated at the single-cell level using FluidFM.
Stiefel P, Schmidt FI, Dörig P, Behr P, Zambelli T, Vorholt JA, Mercer J.
Nano Lett. 2012 Aug 8;12(8):4219-27.

external pageSingle-cell analysis of population context advances RNAi screening at multiple levels.
Snijder B, Sacher R, Rämö P, Liberali P, Mench K, Wolfrum N, Burleigh L, Scott CC, Verheije MH, Mercer J, Moese S, Heger T,
Theusner K, Jurgeit A, Lamparter D, Balistreri G, Schelhaas M, De Haan CA, Marjomäki V, Hyypiä T, Rottier PJ, Sodeik B,
Marsh M, Gruenberg J, Amara A, Greber U, Helenius A, Pelkmans L.
Mol Syst Biol. 2012 Apr 24;8:579.

external pageOligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin.
Stoeber M, Stoeck IK, Hänni C, Bleck CK, Balistreri G, Helenius A.
EMBO J. 2012 Apr 13;31(10):2350-64.

external pageCullin-3 regulates late endosome maturation.
Huotari J, Meyer-Schaller N, Hubner M, Stauffer S, Katheder N, Horvath P, Mancini R, Helenius A, Peter M.
Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):823-8.

external pageHistone deacetylase 8 is required for centrosome cohesion and influenza A virus entry.
Yamauchi Y, Boukari H, Banerjee I, Sbalzarini IF, Horvath P, Helenius A.
PLoS Pathog. 2011 Oct;7(10).

external pageBAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol.
Geiger R, Andritschke D, Friebe S, Herzog F, Luisoni S, Heger T, Helenius A.
Nat Cell Biol. 2011 Sep 25;13(11):1305-14.

external pageVaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture.
Schmidt FI, Bleck CK, Helenius A, Mercer J.
EMBO J. 2011 Jul 26;30(17):3647-61.

Reviews

Endocytosis of viruses and bacteria.
Cossart P, Helenius A.
Cold Spring Harb Perspect Biol. 2014 Aug 1;6(8). pii: a016972. doi: 10.1101/cshperspect.a016972.  

Gulping rather than sipping: macropinocytosis as a way of virus entry.
Mercer J, Helenius A.
Curr Opin Microbiol. 2012 Aug;15(4):490-9.

Poxvirus host cell entry.
Schmidt FI, Bleck CK, Mercer J.
Curr Opin Virol. 2012 Feb;2(1):20-7.

Endosome maturation.
Huotari J, Helenius A.
EMBO J. 2011 Aug 31;30(17):3481-500

Late-penetrating viruses.
Lozach PY, Huotari J, Helenius A.
Curr Opin Virol. 2011 Jul;1(1):35-43.

Commentaries

Membranes, viruses, detergents, and endosomes.
Helenius A.
Mol Biol Cell. 2012 Nov;23(21):4157-9.

Vaccinia virus egress: actin OUT with clathrin.
Schmidt FI, Mercer J.
Cell Host Microbe. 2012 Sep 13;12(3):263-5.

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