Matos Group

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The life cycle of sexually reproducing eukaryotes depends on two specialized chromosome segregation programs: mitosis and meiosis. Whereas mitosis drives cellular proliferation and the stable propagation of the genome, meiosis promotes genetic diversity and the formation of haploid gametes, which combine at fertilization to restore the diploid state. Remarkably, both genome stability and genetic diversity/haploidisation depend on the cell’s ability to repair damaged chromosomes using homologous recombination.

We study how cells rewire their DNA repair machinery in order to: 1) promote genetic diversity and haploidisation during meiosis; 2) prevent genomic instability during mitotic proliferation; 3) ensure the efficient disengagement of recombination intermediates prior chromosome segregation and cell division.

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Fri Jun 23 03:43:18 CEST 2017
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