Research

Main content

The Kornmann Laboratory studies the ultrastructural organization of the cell and the biology of organelles. Organelles are separate yet interdependent units of the eukaryotic cells. They provide an appropriate milieu for the catalysis of specific biochemical reactions. On the other hand, the compartimentalization of the cell also creates the need for ultrastructural organization of the cell and communication routes that allow the exchange of metabolites and information across the cell. Our lab focuses mainly on mitochondria and on how mitochondria communicate with their neighboring environment in an integrated fashion.

Specific questions that are of interest to us

How are lipid molecules brought to mitochondrial membranes?

While lipids can use vesicular transport to navigate through the endomembrane, they have to use other means to reach mitochondria. Contact sites between organelles are thought to be lipid exchange platform. In fact, the emerging picture is that lipid exchange at contact sites is not only occurring at mitochondria but is also heavily used within the endomembrane. We study the molecular components of these contact sites and decipher how each contact site contributes to intracellular lipid fluxes in a networked fashion.

ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13.
Alexander B. Lang, Arun T.J. Peter, Peter Walter, and Benoit Kornmann
The Journal of Cell Biology, (2015) New York, NY: Rockefeller University Press.

How is the mitochondrial network maintained through the life cycle of a cell?

Mitochondria form an intricate and dynamic network. This network undergoes massive changes at the onset of mitosis and needs to be reestablished afterwards. We study mitotic-specific mitochondrial transport in human cells and decipher the molecular mechanisms as well as the physiological implications of this phenomenon.

Mitotic redistribution of the mitochondrial network by Miro and Cenp-F.
G. Kanfer, T. Courthéoux, M. Peterka, S. Meier, M. Soste, A. Melnik, K. Reis, P. Aspenström, M. Peter, P. Picotti, and B. Kornmann
Nature Communications, (2015) London: Nature Publishing Group.

Techniques we develop

SATAY

Saturated transposon analysis in yeast

A simple method to identify all genes or portions of genes necessary for the growth of a yeast cell in any particular condition

See our dedicated website.

And the original publication.

Techniques we use

Yeast Molecular Genetics

Lipidomics / Mass Spectrometry

Next Generation Sequencing

Live/ super-resolution fluorescence microscopy

In vitro reconstitution

 
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Fri Jun 23 15:37:06 CEST 2017
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